• Entecavir

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SKU: E030

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Description
Entecavir is a deoxyguanosine analog antiviral drug and is commonly used to treat hepatitis B (HBV) infections.

    CAS Number

    209216-23-9

    Molecular Formula

    C12H15N5O3

    Molecular Weight

    277.28

    Mechanism of Action

    Entecavir inhibits DNA synthesis by targeting HBV reverse transcriptase.

    Storage Conditions

    -20°C

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    Impurity Profile

    Single impurity: Not more than 0.1%
    Total impurities: Not more than 0.3%

    Water Content (Karl Fisher)

    5.5 - 7.0%

    Optical Rotation

    +24° - +28°

    Assay

    (Anhydrous basis): 98.0 - 102.0%

    Residue On Ignition

    Not more than 0.1%

    Heavy Metals

    Not more than 10ppm

    Residual Solvents

    Tetrahydrofuran: Not more than 720ppm
    Methanol: Not more than 1000ppm
    Ethyl Acetate: Not more than 5000ppm

References

    References

    Menéndez-Arias, Luis, Mar Álvarez, and Beatriz Pacheco. "Nucleoside/nucleotide Analog Inhibitors of Hepatitis B Virus Polymerase: Mechanism of Action and Resistance." Current Opinion in Virology 8 (2014): 1-9. Web.

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