• Enopeptin A packaged and labeled in glass vial.

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SKU: E040

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Enopeptin A is an unusual depsipeptide featuring a pentaenone side chain, reported as an antiviral by researchers at RIKEN in 1991. Enopeptin A has potent antibacterial activity against Gram positive and Gram negative bacteria, including MRSA. Enopeptin A is the most non-polar of the acyldepsipeptide (ADEP) antibiotics which include the recently rediscovered compounds, A54556 A and B.

Enopeptin A is soluble in ethanol, methanol, DMF or DMSO.

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    Molecular Formula


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    Mechanism of Action

    Like other acyldepsipeptide (ADEP) antibiotics, Enopeptin A acts by activating and disregulating Clp-family proteins.

    Storage Conditions




    Yellow solid



    The structure of enopeptins A and B, novel depsipeptide antibiotics. Koshino H. et al. Tetrahedron Letters 1991, 32, 7707.

    Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity. Osada H. et al. J. Antibiot. 1991, 44, 1436.

    Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al. Nature Struct. Mol. Biol. 2010, 17, 471.

    Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics. Hinzen B. et al. Chem. Med. Chem. 2006, 1, 689.

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