• Deacetylravidomycin packaged and labeled in glass vial.

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SKU: D037

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Description
O-Deacetylravidomycin is the more active and stable analogue of the ravidomycin complex produced by Streptomyces ravidus. The metabolite shows potent, light-dependent antitumor activity. O-Deacetylravidomycin, like the related gilvocarcins and chrysomycins, is thought to act as a topoisomerase II inhibitor.

O-Deacetylravidomycin is soluble in DMF and DMSO and is moderately soluble in methanol and ethanol. 

    CAS Number

    88580-27-2

    Molecular Formula

    C29H31NO8

    Molecular Weight

    521.6

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow Solid

References

    References

    New ravidomycin analogues, FE35A and FE35B, apoptosis inducers produced by Streptomyces rochei. Yamashita N. et al. J. Antibiot. 1998, 51, 1105.

    Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of human topoisomerase II. Lorico A. et al. Eur. J. Cancer 1993, 29A, 1985.

    Light-dependent activity of the antitumor antibiotics ravidomycin and desacetylravidomycin. Greenstein M. et al. Antimicrob. Agents Chemother. 1986, 29, 861.

    Chemical modification of ravidomycin and evaluation of biological activities of its derivatives. Rakhit S. et al. Antimicrob. Agents Chemother. 1986, 29, 861.

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