• Dasatinib

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SKU: D074

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Description
Dasatinib is multitarget kinase inhibitor used in the treatment of leukemia. Dasatinib's main targets are tyrosine kinase BCR/ABL, which works to provide the cancer cell with ATP at an uncontrolled rate causing rapid division, and the SRC family of kinases, which contribute to the malignant migration of cancers.

Dasatinib is slightly soluble in ethanol and methanol, but insoluble in water.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 

    CAS Number

    302962-49-8

    Molecular Formula

    C22H26ClN7O2S

    Molecular Weight

    488.01

    Mechanism of Action

    Dasatinib is able to bind to the kinase domain of both the active and inactive forms of BCR/ABL for more effective inhibiting power.

Specifications

    Appearance

    White to off-white powder

References

    References

    Tokarski, J. S. (2006). The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants. Cancer Research, 66(11), 5790-5797. doi:10.1158/0008-5472.can-05-4187

    Buettner, R., Mesa, T., Vultur, A., Lee, F., & Jove, R. (2008). Inhibition of Src Family Kinases with Dasatinib Blocks Migration and Invasion of Human Melanoma Cells. Molecular Cancer Research, 6(11), 1766-1774. doi:10.1158/1541-7786.mcr-08-0169

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