• Collismycin packaged and labeled in glass vial.

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SKU: C181

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Description
Collismycin is a rare and unusual antibiotic belonging to the caerulomycin class, containing a core 2,2'-bispyridyl with an oxime substituent, produced by a strain of Streptomyces and discovered by researchers from Kirin, Japan in 1994. Collismycin was discovered as a potent inhibitor of glucocorticoid receptor binding. Collismycin has weak to moderate activity against bacteria, fungi and tumor cell lines. More recently, collismycin has been found to be a potent and selective neuroprotective agent against oxidative stress. Other recent publications have focused on the biosynthesis of collismycin as a route to the production of related analogues.

Collismycin is soluble in ethanol, methanol, DMF and DMSO.  

    CAS Number

    158792-24-6

    Molecular Formula

    C13H13N3O2S

    Molecular Weight

    275.3

    Storage Conditions

    -20°C

Specifications

    Appearance

    White to off white solid

References

    References

    Caerulomycin, a new antibiotic from Streptomyces caeruleus Baldacci: I. Production, isolation, assay and biological properties. Funk A. & Divekar P.V. Can. J. Microbiol. 1959, 5, 317.

    Collismycin A and B, novel non-steriodal inhibitors of dexamethasone glucocorticoid receptor binding. Shindo K. et al. J. Antibiot. 1994, 47, 1072.

    Engineering the biosynthesis of the polyketide-nonribosomal peptide collismycin A for generation of analogs with neuroprotective activity. Garcia I. et al. Chem Biol. 2013, 20, 1022.

    Collismycin A biosynthesis in Streptomyces sp. CS40 is regulated by iron levels through two pathway-specific regulators. Vior N.M. et al. Microbiology 2014, 160, 467.

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