Cefotaxime Sodium, USP is broad-spectrum, third-generation cephalosporin. It interferes with bacterial peptidoglycan synthesis. Cefotaxime Sodium is freely soluble in aqueous solution.
We also offer:
- Cefotaxime Sodium, USP (C011)
Cefotaxime Sodium, USP conforms to United States Pharmacopoeia specifications.
CAS Number
64485-93-4
Molecular Formula
C16H16N5NaO7S2
Molecular Weight
447.45
Mechanism of Action
Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Cefotaxime Sodium however, is largely resistant to β-lactamases.
Storage Conditions
-20°C
Tariff Code
2941.90.5000
Spectrum
Cefotaxime Sodium has broad-spectrum activity against a wide variety of Gram-positive and Gram-negative bacteria. However, unlike many cephalosporin antibiotics, cefotaxime sodium is not effective against Pseudomonas aeruginosa.