• Borrelidin packaged and labeled in glass vial.

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SKU: B041

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Description
Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.

Borrelidin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    7184-60-3

    Molecular Formula

    C28H43NO6

    Molecular Weight

    489.6

    Mechanism of Action

    Borrelidin is a selective inhibitor of bacterial and eukaryal threonyl-tRNA synthetase and is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    White Lyophilisate

References

    References

    A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. Ruan T. et al. , J. Biol. Chem. 2005, 280, 571. 

    Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. Wakabayashi T. et al. , J. Antibiot. 1997, 50, 671.

    Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. Kawamura T. et al. , J. Antibiot. 2003, 56, 709.

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