• Blasticidin A packaged and labeled in glass vial.

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SKU: B051

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Description

Blasticidin A is a high molecular weight tetramic acid isolated from S. resistomycificus in 1955.  It has broad-spectrum antifungal and antibacterial activity.  Like many tetramic acids, Blasticidin A is isolated as the stable calcium salt/complex. Blasticidin A and closely related Aflastatin A are specific inhibitors of the production of the aflatoxin produced  by the fungus Aspergillus parasiticus.

 Blasticidin A is soluble in DMF, DMSO and methanol and is moderately soluble in water and ethanol.

    CAS Number

    100513-53-9

    Molecular Formula

    C58H107NO23

    Molecular Weight

    1186.5

    Mechanism of Action

    Blasticidin A inhibits aflatoxin production by Aspergillus parasiticus. It also decreases ribosomal protein levels and inhibits protein synthesis in S. cerevisiae.

    Storage Conditions

    -20°C

Applications

    Microbiology Applications

    Blasticidin A has antifungal and antibacterial activity. It inhibits aflatoxin production in Aspergillus parasiticus without affecting fungal growth.

Specifications

    Appearance

    Yellow tan solid

References

    References

    Fukunaga K et al (1955) Blasticidin, a new anti-phytopathogenic fungal substance. Part I. Bull. Agr. Chem. Soc. Jpn. 1955, 19(3): 181-188

    Sakuda S et al (2000) Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus. J. Antibiot. (Tokyo) 53 (11): 1265-1271. PMID 11213287

    Yoshinari T et al (2010) Inhibitory activity of blasticidin A, a strong aflatoxin production inhibitor, on protein synthesis of yeast: Selective inhibition of aflatoxin production by protein synthesis inhibitors J. Antibiot. (Tokyo) 63(6): 309-314 PMID 20414321

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