Beta-lactamase Inhibitors

Beta-lactamase inhibitors description, mechanism, and combination with beta lactam antibiotics.
One of the leading mechanisms of resistance to beta lactam antibiotics is the production of beta-lactamase enzymes produced by resistant bacteria. Beta-lactamases are enzymes that break open the beta-lactam ring in beta-lactam antibiotics through hydrolysis which renders the antibiotic inactive. Beta-lactamase inhibitors such as sulbactam, tazobactam, and clavulanate are compounds that irreversibly bind to, and inhibit beta-lactamase enzymes. Beta-lactamse inhibitors can be used in combination with beta-lactam antibiotics to increase antibiotic activity.
 
Ampicillin/sulbactam (2:1) packaged and labeled.
Ampicillin is a member of the extended spectrum β-lactam family and similar in structure to penicillin. Resistance to Ampicillin is...
Tazobactam packaged and labeled.
Tazobactam is a penicillin derived β-lactamase inhibitor.TOKU-E offers two forms of tazobactam: tazobactam (T001) and tazobactam sodium (T031). Tazobactam is slightly...
Sulbactam sodium packaged and labeled.
Sulbactam is a β-lactamase inhibitor used to increase potency of β-lactam antibiotics.
Sulbactam packaged and labeled in glass bottle.
Sulbactam is a β-lactamase inhibitor used to increase potency of β-lactam antibiotics.
Clavulanic acid potassium w/ cellulose (1:1) packaged and labeled.
Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate...
Tazobactam sodium packaged and labeled.
Tazobactam sodium is a penicillin derived β-lactamase inhibitor.
Clavulanic acid, lithium salt
Clavulanate lithium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate...
Avibactam
Avibactam is a β-lactamase inhibitor able to inhibit class A and class C enzymes...