• Asukamycin packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: A133

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description
Asukamycin is an unusual trienoic acid amide metabolite produced by Streptomyces nodosus, reported by Omura and colleagues at the Kitasato Institute, Japan, in 1976. Asukamycin belongs to the manumycin class that comprises two trienoic acid amides pivoted on a central cyclohexenone ring to give the molecule an unprecedented angular geometry. Asukamycin is active against Gram positive bacteria, tumor cell lines and protozoans, notably coccidia. Asukamycin's cell toxicity is accompanied by activation of Caspases 3 and 8.

Asukamycin is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    61116-33-4

    Molecular Formula

    C31H34N2O7

    Molecular Weight

    546.6

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow-brown solid

References

    References

    A new antibiotic, asukamycin, produced by Streptomyces. Omura S. et al. J. Antibiot. 1976, 29, 876.

    The manumycin-group metabolites. Sattler I. et al. J. Antibiot. 2000, 53, 221.

    Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis. Shipley P.R. et al. Int. J. Mol. Med. 2009, 24, 711.

Other Items In This Category