• Artesunate

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SKU: A096

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Description
Artesunate is an anti-malarial drug and has been found to be effective against multidrug-resistant Plasmodium falciparum and P. vivax malaria. Artesunate has also been found to have anti-cancer activity against leukemia and colon cancer cell lines.

    CAS Number

    88495-63-0

    Molecular Formula

    C19H28O8

    Molecular Weight

    384.42

    Mechanism of Action

    Artesunate causes double stranded breaks in parasite DNA which leads to a buildup of intracellular reactive oxygen species (ROS).

    Storage Conditions

    ≤30°C

    Spectrum

    Artesunate is active against Plasmodium falciparum and P. vivax.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Artemisia annua

    Impurity Profile

    Single impurity: Not more than 0.5%
    Total impurities: Not more than 2.0%

    pH

    3.5 - 5.0

    Melting Point

    132°C - 136°C

    Optical Rotation

    +4.5 - +6.5

    Assay

    (HPLC, On dried basis): 98.0% - 102.0%

    Loss on Drying

    Not more than 0.5%

    Residue On Ignition

    Not more than 0.1%

    Heavy Metals

    Not more than 20ppm

References

    References

    Efferth, Thomas, Heather Dunstan, Axel Sauerbrey, Hayato Miyachi, and Christopher Chitambar. "The Anti-malarial Artesunate Is Also Active against Cancer." Int J Oncol International Journal of Oncology (2001): n. pag. Web.

    Gopalakrishnan, Anusha M., and Nirbhay Kumar. "Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species." Antimicrobial Agents and Chemotherapy Antimicrob. Agents Chemother. 59.1 (2014): 317-25. Web.

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