Antifungal activity of Myriocin on clinically relevant Aspergillus fumigatus strains producing biofilm

Myriocin is known to inhibit sphingolipid synthesis, and was originally investigated for use in cancer treatment inhibiting proliferation without triggering cell death. Sphingolipids are an important component of the cell membrane functioning as structure and part of signaling pathways. Perdoni et al. in this paper investigated sphingolipids as a target for antifungal activity in addition to myriocin's anticancer promise. They found that Aspergillus fumigatus treated with myriocin showed usually short, highly-branched hyphae and antifungal activity against planktonic and biofilm-based sessile cells.

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