Eukaryotic Cell Culture Applications

Since the compound selectively targets fungal cells and does not exhibit cytotoxicity to mammalian cells in vitro (Harris and Coote, 2010), it is useful in cell culture to combat Candidaand Aspergillus spp .

Form

Powder

Appearance

White crystalline powder

Source

Semi-synthetic

Impurity Profile

Impurities (HPLC): Not more than 2.0%

Water Content (Karl Fischer)

Not more than 2.0%

pH

6.5 - 7.5

Heavy Metals

Not more than 5ppm

References

Harris MR and Coote PJ (2010) Combination of caspofungin or anidulafungin with antimicrobial peptides results in potent synergistic killing of Candida albicans and Candida glabrata in vitro. Int. J. Antimicrob. Agents 35(4):347-356 PMID 20106636

Odds, FC, Brown AJ, Gow NA (2003) Antifungal Agents: Mechanisms of action. Trends Microbiol.11(6): 272-279 PMID 12823944

Pfaller, M A et al. In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp, including 315 isolates resistant to fluconazole” J. Clinical Microbiol. 43(11):5425-5427

Salas V et al (2011) Anidulafungin in treatment of experimental invasive infection by : in vitro activity, (1-->3)-beta-D-glucan and mannan serum levels, histopathological findings, and in vivo efficacy. Antimicrob. Agents Chemother. 55 (11):4985-4989 PMID 21844324

Vazquez, JA and Sobel JD (2006) Anidulafungin: A novel echinocandin. Clin. Infect. Dis. 43(2):215-222 PMID 16779750

Available Documents

• SDS
• Product Data Sheet