• Anidulafungin

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SKU: A041

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Description

Anidulafungin is a semi-synthetic echinocandin antifungal that is effective against Candida spp.   Anidulafungin inhibits fungal cell wall synthesis. It is useful in pharmacotherapy and cell culture research applications.

    CAS Number

    166663-25-8

    Molecular Formula

    C58H73N7O17

    Molecular Weight

    1140.24

    Mechanism of Action

    Anidulafungin inhibits the enzyme (1→3)-β-D-glucan synthase, which is important in fungal cell wall synthesis.

    Storage Conditions

    -20°C

    Spectrum

    Anidulafungin is active against Candida and Aspergillus spp.

Applications

    Eukaryotic Cell Culture Applications

    Since the compound selectively targets fungal cells and does not exhibit cytotoxicity to mammalian cells in vitro (Harris and Coote, 2010), it is useful in cell culture to combat Candidaand Aspergillus spp .

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Semi-synthetic

    Impurity Profile

    Impurities (HPLC): Not more than 2.0%

    Water Content (Karl Fischer)

    Not more than 2.0%

    pH

    6.5 - 7.5

    Heavy Metals

    Not more than 5ppm

References

    References

    Harris MR and Coote PJ (2010) Combination of caspofungin or anidulafungin with antimicrobial peptides results in potent synergistic killing of Candida albicans and Candida glabrata in vitro. Int. J. Antimicrob. Agents 35(4):347-356 PMID 20106636

    Odds, FC, Brown AJ, Gow NA (2003) Antifungal Agents: Mechanisms of action. Trends Microbiol.11(6): 272-279 PMID 12823944

    Pfaller, M A et al. In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp, including 315 isolates resistant to fluconazole” J. Clinical Microbiol. 43(11):5425-5427

    Salas V et al (2011) Anidulafungin in treatment of experimental invasive infection by : in vitro activity, (1-->3)-beta-D-glucan and mannan serum levels, histopathological findings, and in vivo efficacy. Antimicrob. Agents Chemother. 55 (11):4985-4989 PMID 21844324

    Vazquez, JA and Sobel JD (2006) Anidulafungin: A novel echinocandin. Clin. Infect. Dis. 43(2):215-222 PMID 16779750

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