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Description
Alamethicin F50 is a neutral linear peptaibol complex with potent antibiotic activity, containing 20 "amino acids" with acetyl and phenylalaninol termini, produced by Trichoderma sp.. Alamethicin F50 is co-produced with an acidic linear peptaibol complex (alamethicin F30). Alamethicin itself is a variable mixture of the acidic and neutral components. In general, reports on alamethicin do not specify the ratio of F50 to F30 in the complex and comparative data between the complexes is scant.

Alamethicin F50 is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    56165-93-6

    Molecular Formula

    C92H151N23O24

    Molecular Weight

    1963.4

    Mechanism of Action

    Alamethicin F50 acts an ionopohore, transporting ions through membranes and artificial lipid membranes. Alamethicin F50 forms voltage-dependent ion channels in lipid bilayer membranes.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Off-white solid

References

    References

    A polypeptide antibacterial agent isolated from Trichoderma viride. Meyer C.E. & Reusser F. Experientia 1967, 23, 85. 

    Chemical nature and sequence of alamethicin. Martin D.R. & Williams R.J.P. Biochem. J. 1976, 153, 181. 

    Alamethacin adsporption to a planar lipid bilayer. Vodyanoy I. et al. Bipophys J. 1988, 53, 649. 

    Sequences of alamethicins F30 and F50 reconsidered and reconciled. Kirschbaum J. Peptide Sci. 2003, 9, 799.

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