• Acyclovir (Acycloguanosine)

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SKU: A090

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Description
Acyclovir (acycloguanosine) is a synthetic purine nucleoside analog and is used as an antiviral medication for the treatment of herpes simplex virus (HSV), shingles, and chickenpox.

Synonyms: acycloguanosine, ACV, Zovirax, 9-[(2-Hydroxyethoxy)methyl]guanine

    CAS Number

    59277-89-3

    Molecular Formula

    C8H11N5O3

    Molecular Weight

    225.21

    Mechanism of Action

    Acyclovir (acycloguanosine) is converted to acyclovir triphosphate (ACV-TP) by viral enzymes which inactivates HSV DNA polymerases.

    Spectrum

    acyclovir (acycloguanosine) targets most herpesvirus species including HSV-1, HSV-2, cytomegalovirus, Epstein-Barr virus (EBV), and Varicella zoster virus (VZV).

Specifications

    Appearance

    White or almost white crystalline powder

    Impurity Profile

    TLC: Not more than 0.5%
    HPLC, Guanine: Not more than 0.7%
    Single Impurity: Not more than 0.5%
    Total Impurities: Not more than 1.0%

    Water Content (Karl Fischer)

    Not more than 6.0%

    Assay

    (Anhydrous Basis): 98.5% - 101.0%

    Sulfated Ash

    Not more than 0.1%

    Heavy Metals

    Not more than 10ppm

References

    References

    Elion, Gertrude B. "Mechanism of Action and Selectivity of Acyclovir." American Journal of Medicine, 20 July 1982. Web.

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