• A 54556A packaged and labeled in glass vial.

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SKU: A110

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Description
A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.

A 54556A is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    95398-45-1

    Molecular Formula

    C38H50N6O8

    Molecular Weight

    718.8

    Mechanism of Action

    A 54556A acts by activating and dis-regulating Clp-family proteins.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Light tan

References

    References

    A54556 antibiotics and process for production thereof. Michel K.H. and Kastner R.E. U.S. Patent 4,492,650 1985.

    Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al. Nat. Struct. Molec. Biol. 2010, 17, 471.

    Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Sass P. et al. PNAS 2011, 108, 17474.

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