4-Epitetracycline HCl, EvoPure® is a highly purified hydrochloride salt form of 4-Epitetracycline. Under acidic conditions, Tetracycline undergoes an epimerization at the fourth carbon, producing a mixture of Tetracycline and 4-Epitetracycline. This EvoPure product is soluble in water.
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|Application||4-Epitetracycline HCl, EvoPure® can be used as an analytical standard.|
|Mechanism of Action||Tetracycline inhibits the growth of Gram-positive and Gram-negative bacteria by disrupting codon-anticodon interactions at the ribosome, thus blocking protein synthesis. Specifically, Tetracycline binds to the 30S ribosomal subunit and blocks the attachment of charged aminoacyl-tRNA to the A site on the ribosome, preventing peptide elongation.|
|Spectrum||Effective against Gram-positive and Gram-negative bacteria, and Mycoplasma.|
|Molecular Formula||C22H24N2O8 · xHCl (lot specific)|
|Molecular Weight||444.43 g/mol (Free base. Actual molecular weight shown on lot specific certificate of analysis).|
Mazur X, Eppenberger HM, Bailey JE and FUssenegger M (2000) A novel autoregulated proliferation-controlled production process using recombinant CHO cells. Biotechnol and Bioeng. 65(2):144-150
Fernandez AA, Noceda VT, Carrera ES (1969) Simultaneous separation and quantitative determination of tetracycline, anhydrotetracycline, 4-epitetracycline, and 4-epi-anhydrotetracycline in degraded tetracyclines by thin-layer chromatography. J. Pharm. Sci. 58(4):443-446