SKU: D104  / 
    CAS Number: 467214-20-6


    $207.00 - $725.00

    17-Dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG, alvespimycin) is a semi-synthetic derivative of the benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group. DMAG acts by binding to the 90-kDa heat shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localisation of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1α, survivin and telomerase hTERT. DMAG is more potent than geldanamycin and 17-allylamino-17-demethoxygeldanamycin (17AAG) as an inhibitor of Hsp90.

    Molecular Formula  C32H48N4O8

    Schneider C et al (1996)  Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90. Proc. Nat.l Acad Sci. 93:14536

    Onuoha SC et al (2007)  Mechanistic studies on Hsp90 inhibition by ansamycin derivatives. J. Mol. Biol. 372:287. 

    Smith V et al (2005)  Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: Effects on Hsp90 and client proteins in melanoma models. Cancer Chemother Pharmacol. 56:126