Cefoxitin Sodium, USP is the sodium salt of Cefoxitin, a cephamycin β-lactam second-generation cephalosporin that is resistant to β-lactamases. It has activity against several Gram-positive and Gram-negative bacteria. Cefoxitin was discovered in 1972 and developed by Merck and Lilly from Cephamycin C while they were reviewing penicillin-producing bacteria. Cephamycin C, the first cephem, but was highly resistant to several β-lactamases. It was synthesized in order to broaden its spectrum of activity to include Gram-positive bacteria, and this work included more than 300 modifications to the molecule. Cefotixin is resistance to beta-lactamses is in part due to the presence of the 7-alpha-methoxy functional group.
Cefoxitin Sodium is freely soluble in aqueous solution.
We also offer:
- Cefoxitin (C091)
