Cefsulodin sodium packaged and labeled.

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C058100 mg
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  • Description

    Cefsulodin sodium is a third generation cephalosporin antibiotic.

    Recently, TOKU-E has found that the main cause of cefsulodin instability stems from one key impurity in 7-ACA (7-aminocephalosporanic acid- a raw material used in the synthesis of cefsulodin). In order to produce high-purity, high-stability cefsulodin, TOKU-E uses industrial HPLC to remove significant quantities of this impurity in 7-ACA and thus produce ultra-pure, ultra-stable, and ultra-potent cefsulodin.

    Mechanism

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Spectrum

    Cefsulodin sodium has a very limited spectrum specifically targeting Pseudomonas aeruginosa. Other members of the gram positive and gram negative species show little susceptibility.

    • Microbiology Applications

      Cefsulodin sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) primarily against Pseudomonas aeruginosa isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

      • Pseudomonas aeruginosa 128 µg/mL – 512 µg/mL
      • For a complete list of cefsulodin MIC values, click here.

      Media Supplements

      Cefsulodin can be used as a selective agent in several types of isolation media:

      Yersinia Selective Agar - Yersinia selective supplement

      Columbia Blood Agar - Helicobacter pylori Selective Supplement (Dent)

      mTSB - VCC Selective Supplement

      Salmonella Chromogenic Agar - Salmonella Selective Supplement

    Form

    Powder

    Tariff Code

    2941.90.3000

    Related Documents


    For in vitro research use only. Not suitable for human or animal consumption.

  • CAS Number52152-93-9
    Molecular FormulaC22H19N4NaO8S2 · xH2O
    Molecular Weight554.53 (Anhydrous basis)
    FormPowder
    AppearanceWhite or light yellow crystalline powder
    SolubilityWater: Freely soluble
    SourceSynthetic
    Water Content (Karl Fisher)≤5.0%
    Potency (on a dry basis)≥864 µg/mg
    pH3.3-4.8
    Melting Point175°C
    Optical Rotation+16.5° to 20.0°
    Storage Conditions-20°C
    Assay(On Dried Basis): ≤90.0%
  • Cefsulodin Stability Study

    Cefsulodin 0.5mg/mL solution was observed to not degrade over a 4 day span at room temperature. With light additional heating (35°C, 1 hour) the cefsulodin powder didn’t degrade while the solution showed slight degradation.

    Additional heating (35°C, 5 hours) of the solution yielded 6% of degradation of Cefsulodin solution.

    Stability at room temperature for >7 days fell below the >90% purity threshold as well as amount of cefsulodin.

  • References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.