SKU: S103  / 
    CAS Number: 10048-13-2


    $109.00 - $381.50
    Sterigmatocystin is a xanthone produced by several species of Aspergillus, isolated by a number of research groups in the 1950s as a mycotoxin associated with food and grain contamination. Sterigmatocystin is structurally related to the aflatoxins and, while it is considered to be mutagenic, teratogenic and carcinogenic, it is less widespread and potent than the aflatoxins.

    Sterigmatocystin is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.
    Mechanism of ActionSterigmatocystin, in the presence of microsomes, covalently binds to DNA. It uncouples oxidative phosphorylation but, unlike the aflatoxins, does not induce mitochondrial swelling or hinder Ca2+-induced swelling of mitochondria. Sterigmatocystin also inhibits acyl-CoA:cholesterol acyltransferase (ACAT) with selectivity for the ACAT2 isoenzyme.
    ReferencesStudies in the biochemistry of micro-organisms. 99. Metabolic products of Aspergillus versicolor (Vuillemin) Tiraboschi. Birkinshaw J.H. & Hammady I.M.M., Biochem. J. 1957, 65, 162.

    Sterigmatocystin-DNA interactions: Identification of a major adduct formed after metabolic activation in vitro. Essigmann J.M., Proc. Nat. Acad. Sci. USA 1979, 76, 179.

    Inhibitory effect of sterigmatocystin and 5,6-dimethoxysterigmatocystin on ATP synthesis in mitochondria. Kawai K. et al. , Appl. Environ. Microbiol. 1984, 48, 1001.

    Selective inhibition of acyl-CoA:cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species. Sakai K.J., Antibiot. 2008, 61, 568.