Antiparasitics

Delta 2 -Avermectin B1a

Δ2-Avermectin B1a is an irreversible base degradation product of avermectin found in animal treated with avermectin and in the environment. Δ2-Avermectin B1a is formed by rearrangement of the naturally-occurring Δ3-group to the 2-position. Although less...

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Delta-2-Avermectin B1a

Delta-2-Avermectin B1a is a natural,  irreversible base degradation product produced by selective hydrolysis of the terminal saccharide Avermectin under acidic conditions in animals and in the environment.  Delta-2-Avermectin B1a is formed by...

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Delta-2-doramectin

Delta-2-Doramectin is an irreversible base degradation product of doramectin found in animals treated with doramectin and in the environment. ?2-Doramectin is formed by rearrangement of the naturally occurring ?3-group in doramectin to the 2-position...

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Demeclocycline

Demeclocycline, a chlortetracycline analogue produced by a mutagenised strain of Streptomyces aureofaciens, was first isolated in 1957. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by...

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Demeclocycline hydrochloride

Demeclocycline hydrochloride is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for...

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Derquantel

Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel is a potent nematocide and was the first paraherquamide to...

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Diacetylcercosporin

Diacetylcercosporin is a minor hydrophobic analogue of cercosporin produced by several species of the fungal genera, Cercospora and Septoria. Diacetylcercosporin has moderate in vitro activity against Leishmania and chloroquine-sensitive strains of...

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Dichlorophen

Dichlorophen is a tenicide, most often used in the treatment of small mammals. Antifungal, antibacterial and herbicidal activity has also been reported. While dichlorophen has low toxicity to mammals, it is toxic to parasites and aquatic life...

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Diethylcarbamazine citrate salt

Diethylcarbamazine is an anthelmintic drug specific to a few species of parasites. It is commonly used as a combination treatment to target multiple stages of life in parasites. Its effectiveness is such that it is used to treat pathogens in large-scale...

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Dihydrocyclosporin A

Dihydrocyclosporin A is co-metabolite of Cyclosporin A. Dihydrocyclosporin A has no immunosuppressant activity and has found use as a control to determine the role of Cyclosporin A  in pharmacology, particularly for parasitic infections...

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Dihydrospinosyn A aglycone

Dihydrospinosyn A aglycone is an acid degradation product produced by hydrolysis of both saccharide groups of 3'-ethoxy-5,6-dihydrospinosyn J, the major component of the commercial insecticide, Spinetoram. Dihydrospinosyn A aglycone is only weakly active...

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Doramectin

Doramectin is a biosynthetic avermectin derived from a mutant strain of Streptomyces avermitilis, supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the...

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