Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Banksialactone A is the simplest and major analogue of a family of isochromanones isolated from an Australian fungus,Aspergillus banksianus, by researchers at Macquarie University, Australia and Microbial Screening Technologies in 2018. While...
Butyrolactone II is one of a family of four butyrolactones isolated from the fungus, Aspergillus terreus, by Yamamoto andcollaborators at Kanazawa University, Japan in 1983. Butyrolactone II inhibits soybean lipoxygenase (LOX) and α-glucosidase...
Dihydroeuphol is a tetracyclic triterpene isolated from members of the genus Euphorbia. There are no published reports of the biological activity of dihydroeuphol, however its analogue, euphol, has cytotoxic, antinociceptive and antioxidant activity. ...
Tosufloxacin Tosylate is a fluoroquinolone antibacterial agent. It is a small organic compound and racemate, comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate. It can act as a mimetic of the neural glycan LewisX (LeX), thus it can...
Emestrin is a macrocyclic mycotoxin first isolated from Emericella striata by researchers at Hoshi Unveristy, Japan in 1985. Emestrin posseses a unique epidithiodioxopiperazine ring as part of a larger heterologous macrocycle. Emestrin inhibits...
Himbacine is a piperidine alkaloid with a tricyclic lactone scaffold isolated from Galbulimima sp. (Himantandra sp.) by Ritchie and Taylor, University of Sydney, Australia in 1956. Himbacine is a potent M2 muscarinic receptor antagonist with selectivity...
Himbadine is a piperidine alkaloid with a polycyclic scaffold first isolated from Galbulimima sp. a magnolia species native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. The...
Himandridine is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimia sp., a magnolia native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia...
Himgaline is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimima sp., a magnolia native to northern Australia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. There are no specific...
Himbosine is apiperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimima sp., a magnolia species native to Australia and South East Asia, and reported in 1967 by Taylor and co-workers, University of Sydney, Australia. The...
Multiflorenol is a triterpenoid found in the geranium family and other flowering plants, first isolated and the structure elucidated by Khastgir and Sengupta in 1961. Multiflorenol was subsequently isolated by Ritchie and Taylor from the Australian...
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid derived from members of the Crotolaria species, longknown to cause poisoining among livestock. Monocrotaline causes pulmonary artery hypertension, right ventricularhypertrophy, and...