Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Methylspinazarin is a rare naphthoquinone pigment produced by a strain of Streptomyces filipinensis, isolated by Nagatsu and colleagues at Ochanomizu University, Japan in 1973. Methylspinazarin inhibits catechol-O-methyl transferase (COMT) and exhibits a...
Monomethylsulochrin is a benzophenone isolated from Aspergillus fumigatus by Turner, ICI Ltd in 1965. Monomethylsulochrin inhibits eosinophil degranulation. Its dimethyl analogue, sulochrin, inhibits VEGF leading to inhibition of capillary-like tube...
Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile, by Taylor and Ritchie in 1970. More recently, Pluviatolide and the related hinokinin were reported as metabolites of the vine, Aristolochia...
Pyripyropene A is a meroterpenoid isolated from Aspergillus fumigatus and published in 1993 by Omura and co-workers at the Kitasato Institute, Japan. Pyripyropene A has potent acyl-CoA:cholesterol acyltransferase (ACAT) and the isozyme sterol...
Phenylpyropene A is a meroterpenoid isolated from Penicillium griseofulvum by researchers at the Korean Research Institute of Bioscience and Biotechnology in 2002. Phenylpyropene A inhibits conversion of cholesterol to cholesteryl esters via inhibition...
Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of...
Territrem B is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem B is a potent insecticide acting via irreversible inhibition of...
Terrelulamide A is a rare lumazine pseudo-tripeptide metabolite isolated from a marine strain of Aspergillus terreus byresearchers at Seoul National University, Korea reported in 2015. Terrelulamide A is reported as having metabolic effects and improves...
Terpendole I is a polar analog of a rare family of indolediterpenes isolated from Albophoma yamanashiensis, first reported by Omura and colleagues at the Kitasato Institute, Japan in 1995. Terpendole I is a weak inhibitor of ACAT (acylCoA:cholesterol...
Vobtusine is a dimeric indole alkaloid derived from the various species of Voacanga, indigenous to Africa, first reported in 1955. In the Pacific region, vobtusine was successfully isolated from the tree, Voacanga papuana, indigenous to New Guinea...
Voacangine is an indole alkaloid derived from various species of Voacanga, indigenous to Africa. In the Pacific region,voacangine was successfully isolated from Tabernaemontana aurantiaca (syn. Rejoua aurantiaca) from the coastal dsitricts of New Guinea...
Voacamine is an indole alkaloid derived from members of the Voacanga species, indigenous to Africa. In the Pacific region,voacamine was successfully isolated from the small tree, Voacanga papuana, indigenous to New Guinea by Ritchie and Taylor,...