SKU: R028  / 
    CAS Number: 224452-66-8

    Reticulol

    $178.80 - $625.80
    Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model.

    Reticulol is soluble in ethanol, methanol, DMF and DMSO. 
    ReferencesActivity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. Jones R. et al. Antimicrob. Agents Chemother. 2006, 50, 2583.

    Retapamulin. Daum R.S. et al. Nature Reviews Drug Discovery 2007, 6, 865.