SKU: P096  / 
    CAS Number: 58523-30-1

    Pseurotin A

    $103.50 - $361.50
    Pseurotin A is a fungal metabolite with an unusual hetero-spirocyclic ring system. It has potent neuritogenic activity in PC12 phaechromocytoma cells, a useful model for adrenergic neuronal differentiation. Pseurotin A also exhibits chitinase inhibition and acts synergistically with azole antifungal agents.

    Pseurotin A is soluble in ethanol, methanol, DMF and DMSO.
    Mechanism of ActionPseurotin A induces multipolar and branching neurites comparable to β-NGF, an endogenous neurotrophic factor.
    ReferencesNovel neuritogenic activities of pseurotin A and penicillic acid. Komagata D. et al. J Antibiot. 1996, 49, 958.

    Synerazol, a new antifungal antibiotic. Ando O. et al. J Antibiot. 1991, 44, 382.

    Pseurotin, a new metabolite of Pseudeurotium ovalis Stolk having an unusual hetero-spirocyclic system. Bloch P. et al. Helv. Chim. Acta 1976, 59, 133.