SKU: L048

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Description

Levofloxacin HCl is the hydrochloride salt of Levofloxacin.  It is a broad-spectrum fluoroquinolone antibiotic and the optical S-(-) isomer of Ofloxacin. The compound is a DNA gyrase inhibitor, and has been shown to inhibit topoisomerase IV.  Levofloxacin is freely soluble in water.

    CAS Number

    177325-13-2

    Molecular Formula

    C18H20FN3O4•HCl

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase (specifically type II topoisomerase) an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited. It has also been shown to inhibit topoisomerase IV.

    Spectrum

    Levofloxacin is a broad-spectrum antibiotic targeting most aerobic Gram-positive and Gram-negative bacteria.  It is moderately active against anaerobes.  It has shown to be effective for Mycoplasma.  Levofloxacin is effective against pathogens causing pneumonia such as  Streptococcus pneumoniae, and Haemophilus influenzae.

Applications

    Microbiology Applications

    Levofloxacin HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:

      • Haemophilus influenzae 0.00625 µg/mL – 1 µg/mL
      • Streptococcus pneumoniae 0.05 µg/mL - 4 µg/mL
      • For a complete list of Levofloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Off-white to light yellow crystalline powder

    pH

    3.5 - 5.0

    Optical Rotation

    -47° to -52°

    Assay

    (On Dried Basis): Not less than 89.5%

    Loss on Drying

    3.5% - 5.0%

    Residue On Ignition

    Not more than 0.1%

    Heavy Metals

    Not more than 10 ppm

References

    References

    Bebear CM, Renaudin H, Bryskier A, Bebear C (2000) Comparative activities of telithromycin (HMR 3647), levofloxacin, and other Antimicrobial Agents against human Mycoplasmas . Antimicrob. Agents and Chemother.  44 (7) 1980-1982  PMID  10858366

    Davis R and Bryson HM (1994)  Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy. Drugs. 47(4):677-700  PMID 7516863

    Wolfson JS and Hooper DC (1985)  The fluoroquinolones: Structures, mechanisms of action and resistance, and spectra of activity in vitro. Antimicrob. Agents Chemother.  28(4):581-586  PMID  3000292

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