• Tobramycin packaged and labeled.

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SKU: T009

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Description

Tobramycin is an aminoglycoside antibiotic.

TOKU-E offers two forms of tobramycin: tobramycin (T009) and tobramycin sulfate (T010). Both forms are freely soluble in aqueous solution ≥50 mg/mL.

    CAS Number

    32986-56-4

    Molecular Formula

    C18H37N5O9

    Molecular Weight

    467.51

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1010

    Spectrum

    Tobramycin targets primarily gram negative bacteria and is used extensively against Pseudomonas aeruginosa.

Applications

    Microbiology Applications

    Tobramycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa 0.25 µg/mL - 16 µg/mL
    • For a complete list of tobramycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or off-white hygroscopic powder

    Source

    Streptomyces tenebrarius

    Water Content (Karl Fisher)

    ≤ 8.0%

    pH

    9.0-11.0

    Assay

    (On Dried Basis): ≥900 µg/mg

    Residue On Ignition

    ≤ 1.0%

    Heavy Metals

    ≤ 0.003%

References

    References

    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

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