• Tilmicosin packaged and labeled.

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SKU: T008

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Description

Tilmicosin is a slighlty soluble semisynthetic macrolide antibiotic.

    CAS Number

    108050-54-0

    Molecular Formula

    C46H80N2O13

    Molecular Weight

    869.13

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to tilmicosin is commonly attributed to mutations in 50S rRNA preventing tilmicosin binding allowing the cell to synthesize proteins free of error.

    Storage Conditions

    2-8°C

    Tariff Code

    2933.39.6190

    Spectrum

    Tilmicosin primarily targets gram negative bacteria especially those which cause bovine respiratory disease.

Applications

    Microbiology Applications

    Tilmicosin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pasteurella haemolytica 4 µg/mL
    • Pasteurella multocida 2 µg/mL – 32 µg/mL
    • For a complete list of tilmicosin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or off white powder

    Source

    Synthetic

    Impurity Profile

    Individual Impurity: ≤3.0%
    Total Impurities: ≤10.0%
    Cis-isomer: 82.0-88.0%
    Trans-isomer: 12.0-18.0%

    Water Content (Karl Fisher)

    ≤ 5.0%

    Assay

    (On Dried Basis): ≥85.0%

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

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