• Ticarcillin disodium w/Clavulanate potassium (15:1)  packaged and labeled.

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SKU: T020

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Description

Ticarcillin disodium is an extended spectrum β-lactam in the carboxypenicillin family.

TOKU-E offers two forms of ticarcillin disodium: ticarcillin disodium (T027) and ticarcillin disodium w/clavulanate potassium (T020). Both forms are freely soluble in aqueous solution. Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. Ticarcillin disodium can be combined with clavulanate potassium for greater efficacy against β-lactam resistant strains.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 

    CAS Number

    116876-37-0

    Molecular Weight

    N/A

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.10.5000

    Spectrum

    Ticarcillin disodium is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative organisms.

Applications

    Microbiology Applications

    Ticarcillin disodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.2 µg/mL – 0.8 µg/mL
    • Streptococcus pneumoniae 0.1 µg/mL – 1.6 µg/mL
    • For a complete list of ticarcillin disodium MIC values, click here.

    Plant Biology Applications

    Timentin is used in Agrobacterium mediated transformations to control Agrobacterium growth. Carbenicillin and cefotaxime can be used in the same applications, however, a study by Nauerby et. al. (1997) found timentin to be less toxic.

Specifications

    Form

    Powder

    Appearance

    White or off white powder

    Source

    Mixture

    Water Content (Karl Fisher)

    <4.2%

    pH

    5.5-7.5

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

    Nauerby B., Billing K. and Wyndale R., Influence of the antibiotic timentin on plant regeneration compared to carbenicillin and cefotaxime in concentrations suitable for elimination of Agrobacterium tumefaciens. Plant Science, Vol. 3, pp. 169-177, 1997.

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