• Telithromycin packaged and labeled.

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SKU: T015

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Description

Telithromycin is a sparingly soluble (0.3 mg/mL) ketolide (macrolide) antibiotic derived from erythromycin.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 

    CAS Number

    191114-48-4

    Molecular Formula

    C43H65N5O10

    Molecular Weight

    812.00

    Mechanism of Action

    Ketolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to telithromycin is commonly attributed to mutations in 50S rRNA preventing telithromycin binding allowing the cell to synthesize proteins free of error.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.3000

    Spectrum

    Telithromycin targets primarily gram positive bacteria especially those responsible for respiratory tract infections.

Applications

    Microbiology Applications

    Telithromycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Streptococcus pneumoniae 0.003 µg/mL – 0.5 µg/mL
    • Streptococcus pyogenes 0.015 µg/mL - 4 µg/mL
    • For a complete list of telithromycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or off-white crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    ≤3.0%

    Assay

    (HPLC, As Is): ≥98.0%

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

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