• Streptozocin packaged and labeled

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SKU: S009

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Description

Streptozocin is a last resort anti-tumor agent commonly used to treat metastatic cancer of pancreatic islet cells. Streptozocin is freely soluble in aqueous solution (>100 mg/mL).

    CAS Number

    18883-66-4

    Molecular Formula

    C8H15N3O7

    Molecular Weight

    265.22

    Mechanism of Action

    Streptozocin acts as an alkylating agent which damages DNA by adding methyl and other alkyl groups which interfere with normal base pairing.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1050

Applications

    Cancer Applications

    Streptozocin has shown to decrease tumor size and relevant tumor-induced symptoms including hypoglycemia.

    Eukaryotic Cell Culture Applications

    Streptozocin is frequently used to induce diabetes and insulitis for diabetes research in mamalian models.

Specifications

    Form

    Powder

    Appearance

    Pale yellow crystalline powder

    Source

    Streptomyces achromogenes

    Impurity Profile

    α-isomer: ≥75.0%
    Residue on Ignition: ≤0.1%
    Heavy Metals: ≤20ppm

    Water Content (Karl Fisher)

    ≤1.0%

    Optical Rotation

    +39°

    Assay

    (As Is): 98.5-101.5%

References

    References

    Murray-Lyon IM, Eddleston AL, Williams R, Brown M, Hogbin BM, Bennett A, Edwards JC, Taylor KW (1968). "Treatment of multiple-hormone-producing malignant islet-cell tumour with streptozotocin". Lancet 2 (7574): 895–8.

    Broder LE, Carter SK. Pancreatic islet cell carcinoma. II. Results of therapy with streptozotocin in 52 patients . Ann Intern Med 1973;79:108–18.

    Moertel CG, Hanley JA, Johnson LA. Streptozocin alone compared with streptozocin plus fluorouracil in the treatment of advanced islet-cell carcinoma . N Engl J Med 1980;303:1189–94.

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