• Spectinomycin dihydrochloride pentahydrate packaged and labeled.

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SKU: S006

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Description

Spectinomycin is an aminocyclitol antibiotic with a similar mechanism to aminoglycosides.

TOKU-E offers two forms of spectinomycin: spectinomycin DiHCl (S006) and spectinomycin sulfate (S016). In aqueous solution, spectinomycin DiHCl is freely soluble, and spectinomycin sulfate is sparingly soluble (0.150 mg/mL).

    CAS Number

    22189-32-8

    Molecular Formula

    C14H24N2O7 •2HCl •5H2O

    Molecular Weight

    495.35

    Mechanism of Action

    Aminocyclitols target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.5000

    Spectrum

    Spectinomycin primarily targets gram negative bacteria, especially those which cause gonorrhea.

Applications

    Microbiology Applications

    Spectinomycin is commonly as a selective agent to isolate cells that contain aadA spectinomycin resistance genes. Spectinomycin is typically used at concentrations between 50 - 100 µg/mL.

Specifications

    Form

    Powder

    Appearance

    White to off-white powder

    Source

    Streptomyces spectabilis

    Water Content (Karl Fisher)

    ≤ 21.0%

    pH

    4.0-5.0

    Optical Rotation

    +15° to +21°

    Assay

    (On Dried Basis): ≥603 µg/mg

    Sulfated Ash

    ≤ 2.0%

    Heavy Metals

    ≤ 20ppm

References

    References

    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

    Wishart, David. "Sulfamethazine." DrugBank. Web. 10 Sept. 2012.

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