• Sparfloxacin packaged and labeled.

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SKU: S005

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Description

Sparfloxacin is a synthetic fluoroquinolone antibiotic and is sparingly soluble in aqueous solution (0.113 mg/mL).

    CAS Number

    110871-86-8

    Molecular Formula

    C19H22F2N4O3

    Molecular Weight

    392.40

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    ≤30°C

    Tariff Code

    2933.59.3600

    Spectrum

    Sparfloxacin is a broad spectrum antibiotic targeting a wide range of Gram positive, Gram negative, and Mycoplasma species especially those which cause pneumonia.

Applications

    Microbiology Applications

    Sparfloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive, gram negative, and Mycoplasma microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Mycoplasma pneumoniae 0.06 µg/mL – 0.12 µg/mL
    • Streptococcus pneumoniae 0.03 µg/mL - 8 µg/mL
    • For a complete list of sparfloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Yellow Crystalline Powder

    Source

    Synthetic

    Impurity Profile

    Related substances: Not more than 1.0%
    Pyridine: Not more than 0.02%

    Assay

    (Dried Basis): 98.5-102.0%

    Loss on Drying

    Not more than 1.0%

    Residue On Ignition

    Not more than 0.2%

    Heavy Metals

    Not more than 0.002%

    Residual Solvents

    Toluene: Not more than 0.089%
    Chloroform: Not more than 0.006%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

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