• Sisomicin sulfate packaged and labeled.

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SKU: S004

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Description

Sisomicin sulfate is a soluble broad-spectrum aminoglycoside antibiotic, and a dihydro analog of gentamicin C1a sulfate, Evopure.  Sisomicin was first isolated in 1970 from Micromonopora inyoensis, a novel strain at the time, that was obtained from soil samples collected in the Inyo National Forest in California.

Sisomicin sulfate is a bacterial protein synthesis inhibitor that binds to the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibiting translocation.  It is effective against most strains of Klebsiellk spp.Escherichia coliP. aeruginosaEnterobacter and Proteus spp.. It is a potential treatment for conjunctiva. Sisomicin has been used in disk and tube dilution sensitivity tests. 

Sisomicin is generally more potent than gentamicin, and has show effective antibacterial synergy with beta-lactam antibiotics against a large range of bacteria.

Synonyms: Antibiotic 6640, Extramycin, Mensiso, Pathomycin, Sisomin, Rickamicin Sulfate, Ensamycin, Sch 13475

    CAS Number

    53179-09-2

    Molecular Formula

    C19H37N5O7 •2.5 H2SO4

    Molecular Weight

    692.72

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1010

    Spectrum

    Sisomicin is a broad spectrum antibiotic which targets a wide range of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Sisomicin sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 1.6 µg/mL – 3.1 µg/mL
    • Pseudomonas aeruginosa 2 µg/mL
    • For a complete list of sisomicin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White to almost white powder

    Source

    Micromonospora Inyoesis.

    pH

    3.5 - 5.5

    Melting Point

    70-73°C

    Optical Rotation

    +100° to +110°

    Assay

    (On Dried Basis): Not less than 580 µg/mg

    Loss on Drying

    Not more than 15.0%

    Residue On Ignition

    Not more than 1.0%

References

    References

    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

    W. Eugene Sanders, Jr., and Christine C. Sanders. "Sisomicin: A Review of Eight Years' Experience." Reviews of Infectious Diseases 2, no. 2 (1980): 182-95.

    Weinstein, M., Wagman, G. & Waitz, J. Infection (1976) 4(Suppl 4): S285.

    Weinstein, Marvin J., Joseph A. Marquez, Raymond T. Testa, Gerald H. Wagman, Edwin M. Oden, and J. Allan Waitz. "ANTIBIOTIC 6640, A NEW MICROMONOSPORA-PRODUCBD AMINOGLYCOSIDE ANTIBIOTIC." The Journal of antibiotics 23, no. 11 (1970): 551-554.


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