• Sisomicin sulfate packaged and labeled.

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SKU: S004

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Description

Sisomicin sulfate is a soluble broad spectrum aminoglycoside antibiotic related to gentamicin.

    CAS Number

    53179-09-2

    Molecular Formula

    C19H37N5O7 •2.5 H2SO4

    Molecular Weight

    692.72

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1010

    Spectrum

    Sisomicin is a broad spectrum antibiotic which targets a wide range of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Sisomicin sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 1.6 µg/mL – 3.1 µg/mL
    • Pseudomonas aeruginosa 2 µg/mL
    • For a complete list of sisomicin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White to off-white powder

    Source

    Micromonospora Inyoesis.

    pH

    3.5-5.5

    Melting Point

    70-73°C

    Optical Rotation

    +100° to +110°

    Assay

    (On Dried Basis): ≥580 µg/mg

    Loss on Drying

    ≤15.0%

References

    References

    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

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