• Salinomycin sodium packaged and labeled.

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SKU: S002

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Description

Salinomycin is a coccidiostat ionophore antibiotic.

TOKU-E offers two forms of salinomycin: salinomycin (S001) and salinomycin sodium (S002). Salinomycin is slightly soluble in methanol at 10 mg/mL. Salinomycin sodium is insoluble in water, freely soluble in acetone, and 200 mg/mL soluble in ethanol.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

Fangyuan Xie et al. used salinomycin from TOKU-E to study its efficacy toward liver cancer cells when used in combination with chloroquine. Read more here: "Codelivery of salinomycin and chloroquine by liposomes enables synergistic antitumor activity in vitro." 

    CAS Number

    55721-31-8

    Molecular Formula

    C42H69NaO11

    Molecular Weight

    772.98 (anhydrous basis)

    Mechanism of Action

    Salinomycin interacts with the gram positive cell membrane which decreases control of ion permeability. This effect allows ions (K+, Na+, Ca+, Mg2+) to accumulate inside the cell to toxic levels.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1050

    Spectrum

    Salinomycin targets primarily the gram positive cell wall to allow ion transport into the cell. Gram negative organisms are unaffected by salinomycin because of their additional outer membrane.

Applications

    Microbiology Applications

    Salinomycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Clostridium perfringins 0.12 µg/mL – 0.25 µg/mL
    • For a complete list of salinomycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Streptomyces albus

    Impurity Profile

    Arsenic: ≤0.0004%
    Elaiophilin: ≤0.0032%

    pH

    6.5-8.5

    Melting Point

    140-142°C

    Assay

    (Dried Basis): ≥900u/mg

    Loss on Drying

    ≤7.0%

    Heavy Metals

    Not more than 0.002%

References

    References

    Adam Huczynski (2012). "Salinomycin – a New Cancer Drug Candidate". Chemical Biology & Drug Design 79: 235–238.

    Yurkovich, Marie E. et al.; Tyrakis, Petros A.; Hong, Hui; Sun, Yuhui; Samborskyy, Markiyan; Kamiya, Kohei; Leadlay, Peter F. (2011-11-11). "A Late-Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster". ChemBioChem 13 (1): 66–71.

    Gupta, P. et al.; Onder, Tamer T.; Jiang, Guozhi; Tao, Kai; Kuperwasser, Charlotte; Weinberg, Robert A.; Lander, Eric S. (2009-08-13). "Identification of selective inhibitors of cancer stem cells by high-throughput screening". Cell 138 (4): 645–59

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