• Roxithromycin packaged and labeled.

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SKU: R005

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Description

Roxithromycin is a semisynthetic macrolide antibiotic and is sparingly soluble in aqueous solution ( 0.019 mg/mL).

    CAS Number

    80214-83-1

    Molecular Formula

    C41H76N2O15

    Molecular Weight

    837.05

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to roxithromycin is commonly attributed to mutations in 50S rRNA preventing roxithromycin binding allowing the cell to synthesize proteins free of error.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.50.0000

    Spectrum

    Roxithromycin is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria especially those which cause respiratory and urinary tract infections.

Applications

    Microbiology Applications

    Roxithromycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Streptococcus agalactiae 0.06 µg/mL – 0.1 µg/mL
    • Streptococcus pneumoniae 0.125 µg/mL - 2 µg/mL
    • For a complete list of roxithromycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Semi-synthetic

    Impurity Profile

    Impurity A| (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-dideoxy-3-C-methyl-3-O-methyl-汐-l-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-汕-d-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione (erythromycin A)|7540-22-9|C37H67NO13|733.93| Impurity B| 3-O-de(2,6-dideoxy-3-C-methyl-3-O-methyl-汐-l-ribo-hexopyranosyl)erythromycin 9-(E)-[O-[(2-methoxyethoxy)methyl]oxime]|214902-82-6|C33H62N2O12|678.85| Impurity C| erythromycin 9-(E)-oxime|13127-18-9|C37H68N2O13|748.94| Impurity D| erythromycin 9-(Z)-[O-[(2-methoxyethoxy)methyl]oxime]||C41H76N2O15|837| Impurity E| 3∩∩-O-demethylerythromycin 9-(E)-[O-[(2-methoxyethoxy)methyl]oxime]||C40H74N2O15|823.02| Impurity F| 3∩-N-demethylerythromycin 9-(E)-[O-[(2-methoxyethoxy)methyl]oxime]|118267-18-8|C40H74N2O15|823.02| Impurity G| erythromycin 9-(E)-[O-[[(2-methoxyethoxy)methoxy]methyl]oxime]|425365-64-6|C42H78N2O16|867.07| Impurity H| 12-deoxyerythromycin 9-(E)-[O-[(2-methoxyethoxy)methyl]oxime]|107749-06-4|C41H76N2O14|821| Impurity I| 2∩-O-[(2-methoxyethoxy)methyl]erythromycin 9-(E)-[O-[(2-methoxyethoxy)methyl]oxime]||C45H85N2O17|926| Impurity J| erythromycin 9-(E)-[O-[(2-chloroethoxy)methyl]oxime]|134834-12-1|C40H73ClN2O14|841.5| Impurity K| erythromycin 9-(E)-[O-[[2-(hydroxymethoxy)ethoxy]methyl]oxime]||C41H76N2O16|837.03|

    Water Content (Karl Fisher)

    ≤3.0%

    Melting Point

    111-118°C

    Optical Rotation

    -93.0° to -96.0°

    Assay

    (On Dried Basis): 97.0-101.0%

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

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