• Rapamycin packaged and labeled.

click on thumbnail to zoom
SKU: R001

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description

Rapamycin (sirolimus) is a macrolide immunosuppressive and anti-tumor drug. Rapamycin is essentially insoluble in water.

Chen et al. used rapamycin from TOKU-E to study the mammalian target of rapamycin. "AMPA receptor–mTOR activation is required for the antidepressant-like effects of sarcosine during the forced swim test in rats: insertion of AMPA receptor may play a role"

    CAS Number

    53123-88-9

    Molecular Formula

    C51H79NO13

    Molecular Weight

    914.17

    Mechanism of Action

    Rapamycin complexes with FK-binding protein (FKBP12) and inhibits mTOR (FRAP, RAFT), a member of the phosphoinositide kinase-related kinase (PIKK) family.

    Storage Conditions

    -20°C

Applications

    Cancer Applications

    Rapamycin suppresses the immune system by preventing T-cell and B-cells from responding to IL-2, a cytokine that would otherwise induce cell proliferation. These properties are especially useful post-transplant to reduce the likelihood of graft rejection. Rapamycin has also demonstrated anti-tumor properties by inducing cellular apoptosis and inhibiting cell division.

Specifications

    Form

    Powder

    Appearance

    White or off-white powder

    Source

    Streptomyces Hygroscopicus

    Melting Point

    183-185ºC

    Loss on Drying

    ≤0.2%

References

    References

    Law, B. K., and Et Al. "Rapamycin: An Anti-cancer Immunosuppressant?" Critical Reviews in Oncology and Hematology 56.1 (2005): 47-60. www.ncbi.gov. Oct. 2005. Web. 30 Aug. 2012.

    Dumont, F. J., and Su Q. "Mechanism of Action of the Immunosuppressant Rapamycin." Life Sciences 58.5 (1996): 373-95. www.ncbi.gov. Web. 30 Aug. 2012.

Other Items In This Category