• Pefloxacin mesylate dihydrate packaged and labeled.

click on thumbnail to zoom
SKU: P004

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description

Pefloxacin is a synthetic fluoroquinolone antibiotic.

TOKU-E offers two forms of pefloxacin: pefloxacin (P015) and pefloxacin mesylate dihydrate (P004). Pefloxacin is slightly soluble in aqueous solution at 11.4 mg/mL. Pefloxacin mesylate dihydrate is freely soluble in aqueous solution.

    CAS Number

    149676-40-4

    Molecular Formula

    C17H20FN3O3 · CH4O3S •2H2O

    Molecular Weight

    465.49

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    2-8°C

    Tariff Code

    2933.59.3600

    Spectrum

    Pefloxacin is a broad spectrum antibiotic which targets a wide range of gram positive and gram negative organisms including a few Mycoplasma species.

Applications

    Microbiology Applications

    Pefloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive, gram negative, and Mycoplasma microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Helicobacter pylori 1 µg/mL - 8 µg/mL
    • Mycoplasma bovis 8 µg/mL
    • For a complete list of pefloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Cream colored powder

    Source

    Synthetic

    Impurity Profile

    Impurity A| 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (demethylated pefloxacin or norfloxacin)|70458-96-7|C16H18FN3O3|319.331| Impurity B| 6-chloro-1-ethyl-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (chlorinated homologue of pefloxacin)||C17H20ClN3O3|349.81| Impurity E| 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)quinoline-4(1H)-one (decarboxylated pefloxacin)||C16H20FN3O|389.35| Impurity D| 4-(3-carboxy-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)-1-methylpiperazine 1-oxide (N-oxide of pefloxacin)|85145-21-7|C17H20FN3O4|349.36| Impurity C| 1-ethyl-6-fluoro-5-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (isopefloxacin)|70458-92-3|C17H20FN3O3|333.36| Impurity F| 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (N-ethyl acid) (norfloxacin impurity A)||C12H9ClFNO3|269.66| Impurity G| ethyl 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (N-ethyl ester)|||| Impurity H| 5-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (iso-N-ethyl acid)|

    pH

    3.5-4.5

    Melting Point

    271°C

    Assay

    ≥99.0%

    Loss on Drying

    ≤8.5%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

Other Items In This Category