• Pefloxacin packaged and labeled.

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SKU: P015

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Description

Pefloxacin is a synthetic fluoroquinolone antibiotic.

TOKU-E offers two forms of pefloxacin: pefloxacin (P015) and pefloxacin mesylate dihydrate (P004). Pefloxacin is slightly soluble in aqueous solution at 11.4 mg/mL. Pefloxacin mesylate dihydrate is freely soluble in aqueous solution.

    CAS Number

    70458-92-3

    Molecular Formula

    C17H20FN3O3

    Molecular Weight

    333.36

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    2-8 °C, protect from light

    Tariff Code

    2933.59.3600

    Spectrum

    Pefloxacin is a broad spectrum antibiotic which targets a wide range of gram positive and gram negative organisms including a few Mycoplasma species.

Applications

    Microbiology Applications

    Pefloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive, gram negative, and Mycoplasma microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Helicobacter pylori 1 µg/mL - 8 µg/mL
    • Mycoplasma bovis 8 µg/mL
    • For a complete list of pefloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Light yellow powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤ 3.0%

    Assay

    (As Is): ≥99.0%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

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