• Oxacillin sodium packaged and labeled.

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SKU: O006

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Description

Oxacillin sodium is a freely soluble (50 mg/mL) narrow spectrum β-lactam antibiotic of the penicillin class.

    CAS Number

    7240-38-2 (monohydrate)

    Molecular Formula

    C19H18N3NaO5S (anhydrous basis)

    Molecular Weight

    423.42 (anhydrous basis)

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Oxacillin however, is resistant to the degradative effects of β-lactamases.

    Storage Conditions

    2-8 °C.

    Tariff Code

    2941.10.3000

    Spectrum

    Oxacillin is used primarily against gram positive organisms namely resistant Staphylococcus species.

Applications

    Microbiology Applications

    Oxacillin sodium is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Staphylococcus aureus 0.125 µg/mL - 8 µg/mL
    • Staphylococcus epidermidis 0.125 µg/mL - 16 µg/mL
    • For a complete list of oxacillin MIC values, click here.

    Media Supplements

    Oxacillin can be used as a selective agent in several types of isolation media:

    ORSAB - ORSAB Selective Supplement

    Fox et al. used oxacillin sodium from TOKU-E to study its synergistic effects with blue light irradiation against Staphylococcus aureus. "Investigating Inhibitory Synergy between Blue Light Irradiation and Antibiotic Treatment of Staphylococcus aureus." 

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    3.5-5.0%

    pH

    4.5-7.5

    Assay

    (On dried basis): 815-950µg/mg

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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