• Moxifloxacin hydrochloride packaged and labeled.

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SKU: M033

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Description

Moxifloxacin HCl is a broad spectrum fourth generation fluoroquinolone antibiotic. Moxifloxacin HCl is sparingly soluble in aqueous solution at 0.168 mg/mL.

    CAS Number

    186826-86-8

    Molecular Formula

    C21H24FN3O4 · HCl

    Molecular Weight

    437.90

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    2-8°C

    Tariff Code

    2933.49.2600

    Spectrum

    Moxifloxacin is a broad spectrum antibiotic commonly used against bacteria which cause sinus and lung infections.

Applications

    Microbiology Applications

    Moxifloxacin HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.008 µg/mL – 0.25 µg/mL
    • Streptococcus pneumoniae 0.03 µg/mL - 8 µg/mL
    • For a complete list of moxifloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Yellow powder

    Source

    Synthetic

    Impurity Profile

    Impurity A| 1-Cyclopropyl-6,8-difluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Difluoro Analog|151213-15-9|C20H21F2N3O3|389.40| Impurity B| 1-Cyclopropyl-6,8-dimethoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Dimethoxy Analog||C22H27N3O5|413.47| Impurity C| 1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Ethyl Analog||C22H26FN3O4|415.46| Impurity D| 1-Cyclopropyl-8-fluoro-6-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Isomer|1029364-77-9|C21H24FN3O4|401.43| Impurity E| 1-Cyclopropyl-6-fluoro-8-hydroxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Desmethyl Analog||C20H22FN3O4|387.4| Moxifloxacin Decarboxy Analog| Decarboxy Moxifloxacin;1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline||C20H24FN3O2|357.42| Moxifloxacin Difluoro Hydroxy Impurity| 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid|154093-72-8|C13H9F2NO4|281.21| Moxifloxacin Difluoro Methoxy Impurity| 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid|112811-72-0|C14H11F2NO4|295.24| Moxifloxacin N-Methyl Analog| 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-1-methyl-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride||C22H27ClFN3O4|451.92| Moxifloxacin Trifluoro Ethyl Ester| 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester|94242-51-0|C15H12F3NO3|311.26| Moxifloxacin Trifluoro Impurity| 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid|94695-52-0|C13H8F3NO3|283.20| Moxifloxacin Methyl Ester| 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid methyl ester|721970-35-0|C22H26FN3O4|415.46| Moxifloxacin Hydrochloride| 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride|186826-86-8|C21H25ClFN3O4|437.89|

    Water Content (Karl Fisher)

    ≤4.5%

    pH

    3.9-4.6

    Assay

    (HPLC, As Is): ≥98.0%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

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