SKU: M021

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Description

Moxalactam sodium is a third generation cephalosporin antibiotic.

TOKU-E offers two forms of moxalactam: moxalactam sodium (M021) and moxalactam diammonium salt (M032). Moxalactam sodium is freely soluble in aqueous solution at 50 mg/mL. Moxalactam diammonium salt is sparingly soluble in aqueous solution at 0.751 mg/mL.

    CAS Number

    64953-12-4

    Molecular Formula

    C20H18N6Na2O9S

    Molecular Weight

    564.44 g/mol

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8 °C

    Spectrum

    Moxalactam targets primarily gram negative bacteria especially those which cause meningitis because of its ability to cross the blood brain barrier.

Applications

    Microbiology Applications

    Moxalactam sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.03 µg/mL – 0.12 µg/mL
    • For a complete list of moxalactam MIC values, click here.

    In addition to its use in AST, moxalactam is used as a media supplement in Oxford Listeria agar to select for Listeria monocytogenes in poultry and processed meats.

Specifications

    Form

    Powder

    Appearance

    White to light yellow powder

    Source

    Synthetic

    Absorbance

    UV max (water): 270 nm (ε 12000)

    Optical Rotation

    [α]D22 = -45° (water)

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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