SKU: M021

Price: make selection(s)

Moxalactam sodium is a third generation cephalosporin antibiotic.

TOKU-E offers two forms of moxalactam: moxalactam sodium (M021) and moxalactam diammonium salt (M032). Moxalactam sodium is freely soluble in aqueous solution at 50 mg/mL. Moxalactam diammonium salt is sparingly soluble in aqueous solution at 0.751 mg/mL.

    CAS Number


    Molecular Formula


    Molecular Weight

    564.44 g/mol

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8 °C


    Moxalactam targets primarily gram negative bacteria especially those which cause meningitis because of its ability to cross the blood brain barrier.


    Microbiology Applications

    Moxalactam sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.03 µg/mL – 0.12 µg/mL
    • For a complete list of moxalactam MIC values, click here.

    In addition to its use in AST, moxalactam is used as a media supplement in Oxford Listeria agar to select for Listeria monocytogenes in poultry and processed meats.





    White to light yellow powder




    UV max (water): 270 nm (ε 12000)

    Optical Rotation

    [α]D22 = -45° (water)



    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

Other Items In This Category