• Mitomycin C packaged and labeled.

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SKU: M009

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Description

Mitomycin C is a bacteriocidal methylazirinopyrroloindoledione antineoplastic antibiotic isolated Streptomyces spp.

    CAS Number

    50-07-7

    Molecular Formula

    C15H18N4O5

    Molecular Weight

    334.33

    Mechanism of Action

    Mitomycin C is activated by reduction in vivo generating oxygen radicals which produce crosslinks in DNA by alkylation. This mechanism ultimately inhibits DNA synthesis which has a bacteriostatic effect.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1050

Applications

    Cancer Applications

    The antiproliferative effects of Mitomycin C may have a role in treating cancer as it was shown to inhibit the progression of dermal Kaposi's sarcoma in patients with renal transplants.

Specifications

    Form

    Powder

    Appearance

    Violet blue crystal

    Source

    Streptomyces Caespitosus

    Water Content (Karl Fisher)

    ≤2.5%

    Potency (on a dry basis)

    ≥970 µg/mg

    pH

    6.0-7.5

    Melting Point

    360°C

References

    References

    Renault, J.; Baron, M; Mailliet P. & al. Heterocyclic quinones.2.Quinoxaline-5,6-(and 5-8)-diones - Potential antitumoral agents. Eur. J. Med. Chem. 16, 6, 545–550, 1981.

    Mao Y.; Varoglu M.; Sherman D.H. (April 1999). "Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces Iavendulae NRRL 2564.". Chemistry and Biology 6 (4): 251–263

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