• Midecamycin packaged and labeled.

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SKU: M007

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Description

Midecamycin is an naturally occurring, broad-spectrum acetoxy-substituted macrolide antibiotic similar in structure to erythromycin.  An acetoxy group is substituted on position 9 of the 16-membered ring and on position 4 of the terminal sugar.   It is naturally produced by Streptomyces mycarofaciens.  It interrupts protein synthesis of Gram-positive and Gram-negative bacteria.  Its metabolites present little to no antimicrobial activity.   It is very soluble in methanol, ethanol, and acidic solutions.  It is soluble in DMSO.

    CAS Number

    35457-80-8

    Molecular Formula

    C41H67NO15

    Molecular Weight

    813.97

    Mechanism of Action

    Midecamycin inhibits bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to Midecamycin is commonly attributed to mutations in 50S rRNA preventing Midecamycin binding allowing the cell to synthesize proteins free of error.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.50.0000

    Spectrum

    Midecamycin is a broad-spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria especially those which cause respiratory, ear, and skin infections. It is active against Streptococci, Staphylococci, Corynebacterium diphtheriae, Bordetella pertussis.

Applications

    Eukaryotic Cell Culture Applications

    In vitro research of Midecamycin showed immunosuppressive properties by inhibiting T-cell responses by suppressing IL-2. These results suggest potential treatment for post-transplant complications and inflammatory diseases.

Specifications

    Form

    Powder

    Appearance

    White or off-white powder

    Source

    Streptomyces mycarofaciens

    Potency (on a dry basis)

    ≥950 µg/mg

    Melting Point

    153-158°C

    Loss on Drying

    ≤1.0%

    Residue On Ignition

    ≤0.2%

    Heavy Metals

    ≤20ppm

References

    References

    Lovmar M and Tanel Tenson T (2003) The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome..  J. Molec. Microbiol. 330 (5):1005-1014  PMID 12860123

    Morikawa K (1994)  Immunomodulatory effects of three macrolides, Midecamycin Acetate, Josamycin, and Clarithromycin, on human T-lymphocyte function in vitro. Antimicrob. Agents. Chemother. 38(11): 2643-2647  PMID 7532933

    Neu HC (1983)  In vitro activity of Midecamycin, a new macrolide antibiotic. Antimicrob. Agents. Chemother. 24(3):443-444  PMID 6639001

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