• icronomicin sulfate packaged and labeled.

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SKU: M018

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Description

Micronomicin Sulfate is the sulfate salt of Micronomicin, a natural aminoglycoside, broad-spectrum antibiotic discovered and and developed by Kyowa Hakko Kogyo Co.  The structure was determined to be 6’-N-methylgentamicin C1a, and it is similar to Gentamicin C in terms of physicochemical and antimicrobial properties but it differs in that it has remarkable activity against some gentamicin C1a-resistant strains.  It targets Gram-positive and Gram-negative bacteria by interfering with bacterial protein synthesis.  Micronomicin Sulfate is freely soluble in water.

    CAS Number

    66803-19-8

    Molecular Formula

    C20H41N5O7 •2.5H2SO4

    Molecular Weight

    708.65

    Mechanism of Action

    Aminoglycoside antibiotics target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1010

    Spectrum

    Gram-positive and Gram-negative bacteria including S. aureus, S. epidermidis, E. coli, and P. aeruginosa.

Specifications

    Form

    Powder

    Appearance

    White to off-white powder

    Source

    Micromonospora sagamiensis var. nonreducans

    pH

    3.5 - 5.5

    Optical Rotation

    +110° to +130°

    Assay

    (On Dried Basis): ≥590 µg/mg

    Loss on Drying

    ≤10.0%

    Sulfated Ash

    Not more than 0.5%

References

    References

    Davis BD (1987)  Mechanism of bactericidal action of aminoglycosides." Microbiol. Rev. 51(3):341-350

    Okachi R et al (1974) A new antibiotic XK-62-2 (Sagamicin).  I. Isolation, physicochemical and antibacterial properties. J. Antibiotics. 27(10):793

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