• Mevastatin (Compactin) packaged and labeled.

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SKU: M004

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Description

Mevastatin is a statin prodrug commonly used to combat hypercholesterolemia. Mevastatin is insoluble in water, and soluble in ethanol and DMSO at 25 mg/mL.

    CAS Number

    73573-88-3

    Molecular Formula

    C23H34O5

    Molecular Weight

    390.51

    Mechanism of Action

    Mevastatin inhibits HMG-CoA reductase, a significant enzyme involved in the cholesterol synthesis pathway.

    Storage Conditions

    2-8 °C

    Tariff Code

    2932.20.5050

Applications

    Cancer Applications

    Research has shown that statin drugs including mevastatin have been able to inhibit melanoma cell growth when high concentrations are used.

Specifications

    Form

    Powder

    Appearance

    Crystals from aqueous ethanol; White powder

    Source

    Penicillium Citrinum.

    Absorbance

    UV max: 230, 237 and 246 nm (log ε 4.28, 4.30, 4.11)

    Melting Point

    152 °C

    Optical Rotation

    [α]D22 = +283° (c = 0.48 in acetone)

    Assay

    ≥95.0%

    Loss on Drying

    ≤2.0%

References

    References

    Eustace, A. J., and et al. "The 3-hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors, Simvastatin, Lovastatin and Mevastatin Inhibit Proliferation and Invasion of Melanoma Cells." BMC Cancer 8.9 (2008): www.ncbi.gov. 16 Jan. 2008. Web. 31 Aug. 2012.

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