• Metronidazole packaged and labeled.

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SKU: M011

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Description

Metronidazole is a nitromidazole antibiotic used specifically against anaerobic bacteria.  In aqueous solution, metronidazole is sparingly soluble at <10 mg/mL.

    CAS Number

    443-48-1

    Molecular Formula

    C6H9N3O3

    Molecular Weight

    171.15 g/mol

    Mechanism of Action

    In anaerobic cells, metronidazole metabolites form unstable molecules which are incorporated into cellular DNA ultimately inhibiting DNA replication and transcription. This unique mechanism has a bactericidal effect on anaerobic cells.

    Storage Conditions

    2-8°C

    Tariff Code

    2933.29.4500

    Spectrum

    Metronidazole is mostly used to combat anaerobic bacteria including Clostridium difficile and Bacteroides fragilis.

Applications

    Microbiology Applications

    Metronidazole is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative anaerobic microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Clostridium difficile 0.25 µg/mL – 0.5 µg/mL
    • Bacteroides fragilis 0.125 µg/mL -1 µg/mL
    • For a complete list of metronidazole MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or yellowish crystalline powder

    Source

    Synthetic

    Impurity Profile

    Any impurity: Not more than 0.1%
    Total impurities: Not more than 0.2%

    Melting Point

    159-163°C

    Loss on Drying

    <0.5%

    Sulfated Ash

    Not more than 0.1%

    Heavy Metals

    Not more than 20ppm

    Residual Solvents

    Methylene oxide: Not more than 0.15 ppm
    Formic acid: Not more than 124 ppm

References

    References

    Nord, Carl Erik, and Charltta Edlund. "Metronidazole Is Still the Drug of Choice for Treatment of Anaerobic Infections." Oxford Journals (2010): n. pag. Clinical Infectious Diseaes. Web. 21 Aug. 2012.

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