• Mecillinam packaged and labeled.

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SKU: M001

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Description

Mecillinam is a broad-spectrum β-lactam antibiotic in the penicillin class, specifically an amidinopenicillin.  This compound was described in 1972 by Lund and Tybring.  It is effective against Gram-negative bacteria.  Mecillinam is sparingly soluble in aqueous solution. 

    CAS Number

    32887-01-7

    Molecular Formula

    C15H23N3O3S

    Molecular Weight

    325.43

    Mechanism of Action

    β-lactams interfere with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBP’s catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.10.5000

    Spectrum

    Mecillinam targets primarily Gram-negative bacteria involved in urinary tract infections. It has minimal activity against Gram-positive organisms.

Applications

    Application

    Mecillinam can be used to study drug interactions.

    Microbiology Applications

    Mecillinam is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram- negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options .
    Representative MIC values include:

    • Escherichia coli 8 µg/mL
    • For a complete list of Mecillinam MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or off-white crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fischer)

    ≤1.0%

    pH

    4.0-6.2

References

    References

    Lund, F., and L. Tybring. 1972. 6 -amidinopenicillanic acids -a new group of antibiotics. Nat.  New Biol. 236(66):135-137  PMID  4402006

    Maioli E, Debbia EA, Gualco L, Marchese A (2008)  In vitro interaction between mecillinam and piperacillin-tazobactam in the presence of azithromycin against members of the Enterobacteriaceae family and Pseudomonas aeruginosa. New Microbiol.31(1):37-46  PMID 18437840

    New HC (1976)  Mecillinam, a novel penicillanic acid derivative with unusual activity against Gram-negative bacteria. Antimicrob. Agents. Chemother. 9(5):793-790

    Pitout JD, Sanders CC, Sanders WE (1997)  Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med  103:51

    Thomas K, Weinbren MJ, Warner M, Woodford N and Livermore D (2006) Activity of mecillinam against ESBL producers in vitro. J. Antimicrob. Chemother. 57(2):367-368

    Tybring L and Melchior NH (1975)  Mecillinam (FL 1060), a 6β-Amidinopenicillanic acid derivative: Bactericidal action and synergy in vitro.  

     
     

     

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