• Mecillinam packaged and labeled.

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SKU: M001

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Description

Mecillinam is an extended spectrum β-lactam antibiotic in the penicillin class and is sparingly soluble in aqueous solution (0.98 mg/mL)

    CAS Number

    32887-01-7

    Molecular Formula

    C15H23N3O3S

    Molecular Weight

    325.43

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.10.5000

    Spectrum

    Mecillinam targets primarily gram negative bacteria responsible for urinary tract infections.

Applications

    Microbiology Applications

    Mecillinam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Escherichia coli 8 µg/mL
    • For a complete list of mecillinam MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or off-white crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    ≤1.0%

    pH

    4.0-6.2

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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