• Irgasan (Triclosan) packaged and labeled.

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SKU: I002

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Description

Irgasan (or triclosan) is a broad spectrum anti-fungal and antibiotic. Irgasan is slightly soluble in water and freely soluble in ethanol and methanol.

    CAS Number

    3380-34-5

    Molecular Formula

    C12H7Cl3O2

    Molecular Weight

    289.54

    Mechanism of Action

    Irgasan demonstrates a bacteriostatic effect by binding to the enoyl-acyl carrier protein reductase; an enzyme involved in fatty acid synthesis. After binding to enoyl-ACP and forming a complex, NAD (nicotinamide adenine dinucleotide) binds and prevents enoyl-ACP from participating in the fatty acid synthesis cycle which inhibits bacterial cell growth.

    Storage Conditions

    2-8 °C

    Tariff Code

    2909.50.4500

Applications

    Microbiology Applications

    Irgasan is used as a media supplement in Pseudomonas and Yersinia isolation agars to inhibit growth of a wide range of gram positive and gram negative bacteria other than Pseudomonas and Yersinia species respectively.

Specifications

    Form

    Powder

    Appearance

    White powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤0.1%

    Melting Point

    56-60 °C

    Assay

    (Dried Basis): 97.0-103.0%

References

    References

    Heath, Richard J. "Mechanism of Triclosan Inhibition of Bacterial Fatty Acid Synthesis."Journal of Biological Chemistry (2010):. Jbc.org. Web. 31 Aug. 2012.

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